منابع مشابه
Antitumor activity of a novel S1P2 antagonist, AB1, in neuroblastoma
Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT06030 (M-HL, LHR, FF); Arroyo Biosciences LLC, Princeton, NJ08540 (RS); Department of Urology and Surgery, Connecticut Children's Medical Center, Hartford, CT 06106 (MH, FF); TCG Life Sciences Limited, Hinjewadi, Pune 411057, India (SJ); Chem-Master International Inc., Stony Brook, NY11794 (ES); Center for Vascu...
متن کاملSynthesis and Study of Antitumor Activity of Substituted Imidazolecarboxamides
In view of potential biological activities of small molecule polyamides, we synthesized some novel N-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5-carboxamide (7a,b), and N-(2-(1-benzyl-2-(alkylthio) -1H-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5-carboxamides (8a,b) as antitumor agents. The antitumor activity of compounds 7a,b and 8a,b was studied at c...
متن کاملAntitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma.
The bioactive lipid sphingosine-1-phosphate (S1P) and its receptors (S1P1-5) play critical roles in many pathologic processes, including cancer. The S1P axis has become a bona fide therapeutic target in cancer. JTE-013 [N-(2,6-dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-hydrazinecarboxamide], a known S1P2 antagonist, suffers from in...
متن کاملPPARδ Activity in Cardiovascular Diseases: A Potential Pharmacological Target
Activation of peroxisome proliferator-activated receptors (PPARs), and particularly of PPARα and PPARγ, using selective agonists, is currently used in the treatment of metabolic diseases such as hypertriglyceridemia and type 2 diabetes mellitus. PPARα and PPARγ anti-inflammatory, antiproliferative and antiangiogenic properties in cardiovascular cells were extensively clarified in a variety of i...
متن کاملAntitumor Activity and Immunomodulatory Effects of Ficus carica Latex
Introduction: There are limited studies on the anti-cancer and immunomodulatory effects of the fig fruit latex. In this study, we aimed to investigate the effect of fig fruit latex on several cancer cell lines as well as its effect on lymphocytes proliferation and cytokines secretion. Methods: After preparing a methanolic extract from fig latex, its effect on various cancer cell lines includin...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2009
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.8.13.9061